Medications for Premature Ejaculation

Medications for Premature Ejaculation

Premature ejaculation is more common than you may think, and effective treatment is available for most sufferers. Discussing your problem with a trained medical practitioner is the first step to obtaining the best new medicine to stop premature ejaculation and have a fantastic sex life again. Let’s take a look at the oral pills and tablets, creams, vitamins and injections available for treating PE to discover what helps the most.

Medications for Premature Ejaculation

Want to know everything about premature ejaculation medications? A full review of oral pills, capsules, injections and natural supplements for PE. What really works? What are scam? Let’s see!

Premature ejaculation (PE) comes with its own particular set of miseries, and many sufferers describe feelings of anger, shame, and a loss of closeness in their relationships.

Untreated premature ejaculation can have a severe negative impact on all aspects of your sex life and personal relationships.
There is no need to suffer in silence. Premature ejaculation is more common than you may think, and effective treatment is available for most sufferers. Discussing your problem with a trained medical practitioner is the first step to obtaining the best new medicine to stop premature ejaculation and have a fantastic sex life again. Let’s take a look at the oral pills and tablets, creams, vitamins and injections available for treating PE to discover what helps the most.

What Is Premature Ejaculation?

When ejaculation always occurs, or nearly always, within about a minute (or even before) the start of intercourse, it is described as premature ejaculation. Broader interpretations may also include those encounters where men ejaculate a lot sooner than they or their partner wish, but when one keeps in mind that men typically ejaculate within 5 minutes of starting intercourse it becomes clear that such broad interpretations should be treated with caution. In fact, occasional premature ejaculation is considered normal. Nevertheless, complaints about premature ejaculation are very common, as at least 1 in 3 men experience this problem at least occasionally. A diagnosis of premature ejaculation is likely if you:

  • always ejaculate within a minute after penetration;
  • nearly always ejaculate within a minute after penetration;
  • are usually or always unable to delay ejaculating during intercourse;
  • if you tend to avoid sex because of your frustration or distress;
  • the problem may occur in all sexual situations, including masturbation.

Medications for Premature Ejaculation

Classification of Premature Ejaculation

Although many men, for different reasons, may at some time or another feel that they ejaculate too soon, their symptoms may not meet the diagnostic criteria for this condition.

Men who experience PE Men who seek help Men who don’t seek help
30% of the population Just 30% of sufferers 70% of sufferers

And now that you are here, this statistic is an eye-opener: Of the 30% of sufferers who do reach out, approximately 70% first look for help on the internet! Only 30% of sufferers go to their doctors first, so if you are looking to explore your options for PE treatment, you are in great company. Never feel embarrassed about your wishes and concerns. If you feel that you usually ejaculate earlier than you wish to during sex, talk to your doctor about your options. Your doctor certainly encounters this discussion regularly and can give you advice or provide a diagnosis and treatment for your condition. The broad categories of premature ejaculation are:

  • natural variable premature ejaculation: periods during which rapid ejaculation occurs, alternating with periods during which normal ejaculation occurs;
  • lifelong (primary) premature ejaculation: PE begins with your first sexual experience and may last your whole life;
  • acquired (secondary) premature ejaculation: when you start experiencing PE after you previously enjoyed normal sexual encounters without ejaculatory problems.

Causes of Premature Ejaculation

Contrary to previous thinking, the problem is not necessarily primarily “in the mind”. Although the exact cause is not known yet, doctors do know that premature ejaculation is caused by a range of complex and interacting biological and psychological factors.

Causes of Premature Ejaculation

Biological Causes Include:

  • inflammation or infection of the urinary tract or prostate;
  • abnormal or fluctuating hormone levels;
  • abnormal or fluctuating levels of neurotransmitters in the brain;
  • drug interactions (prescription or recreational drugs);
  • psychological Factors Include;
  • family or work-related stress;
  • worry about your sexual performance or the possibility of premature ejaculation;
  • feelings of guilt or a poor body image;
  • depression;
  • habits formed during early or solo sexual experiences;
  • anxiety caused by sexual abuse or trauma.

Known Risk Factors For Premature Ejaculation

Relationship problems, work stress, and emotional strain are all recognized risk factors for premature ejaculation. Also, if you suffer from Erectile Dysfunction (ED), your fear of losing your erection could cause you to rush through sex to achieve that elusive satisfaction and you may unknowingly create a pattern of haste in your sexual encounters.

How Can I Beat Premature Ejaculation?

The treatment will depend on the cause of your premature ejaculation and will often include both medication and non-medication treatment methods. Treatment options for premature ejaculation range from counseling and behavioral techniques to prescribing topical anesthetics or drugs. The perfect solution will probably consist of a combination of behavioral techniques and medication and you may need to experiment with the available options until you find the right combination for your situation.

Behavioral Techniques to Beat Premature Ejaculation

Premature Ejaculation

There are a few widely known techniques to help you delay your ejaculation, and these are very successful when combined with one or more of the available medical solutions to completely tame premature ejaculation:

  • if you do not suffer from erectile dysfunction, try masturbating one or two hours before sex to remove some of the urgency and help your sexual encounter to last longer;
  • kegel exercises are great for improving your pelvic floor muscles. Strong pelvic floor muscles not only support the bladder and bowels, but also improve your ability to delay your ejaculation;
  • the “pause-squeeze” sexual technique requires you to find the point at which you are close to ejaculating, and for your partner to squeeze a pressure point at the end of your penis for a few seconds until that urge to ejaculate passes. Repeat this process as required to prolong the sex act;
  • the “stop-start” sexual technique also requires you to closely monitor how near you are to ejaculation and to stop all movement or stimulation before you reach your peak. This method is suitable for those who find the pause-squeeze technique cumbersome or painful.

Medication for PE

Although the FDA has yet to approve any drug specifically for premature ejaculation treatment, there are a number of drugs that are prescribed off-label and are very effective in treating the condition. The list of medications for premature ejaculation includes a type of antidepressant called Selective Serotonin Re-uptake Inhibitors (SSRIs), and also drugs normally used for the treatment of erectile dysfunction. You can even use a combination of drugs with desensitizing sprays or a desensitizing cream which contain an approved form of local (topical) anesthetics.

Topical Anesthetics and Condoms

You can use a condom to decrease sensitivity around the glans area, which can delay ejaculation. Condoms made from thicker latex are more suitable for this purpose. Also, most major condom manufacturers offer specialized condoms containing approved numbing agents, a popular option to prolong sexual encounters. However, users or their partners may consider it a hindrance in circumstances where birth control and/or protection against STDs is not required. There are several numbing agents on the market and you can buy some without a prescription. You apply these topical anesthetic agents to sensitive parts of the penis before intercourse to damp down or dull sensations during sex. Topical anesthetics are quite effective in delaying ejaculation. However, some side effects may include temporary loss of sensation which can be distressing, and in some cases, sexual partners may also experience a loss of sensitivity. Topical anesthetics come in spray or cream formulations and may contain lidocaine, benzocaine, or prilocaine. You should apply the cream or spray to the sensitive parts of your penis about 10 minutes before intercourse to successfully reduce sensation.

Oral Medications

Oral Medications

There are many drugs which are prescribed off-label for their recognized ability to successfully delay ejaculation. Depending on your diagnosis and specific circumstances, your doctor may prescribe either analgesics, antidepressants, phosphodiesterase-5 (PDE5) inhibitors, or a combination of these drugs.


A specific class of antidepressants called SSRIs can effectively delay ejaculation for some men. SSRIs inhibit the neuronal uptake of serotonin (5-HT) in the central nervous system and as a result, demonstrate a very helpful side effect: delayed ejaculation! Examples of SSRIs, which are often prescribed to treat premature ejaculation are Fluoxetine (Prozac), Sertraline (Zoloft), Citalopram (Celexa) and the highly effective Paroxetine (Paxil, Pexeva). In cases where an antidepressant of the SSRI class is not suitable for you, your doctor may prescribe a different class of antidepressant. There are certain TriCyclic Antidepressants (TCAs) that display SSRI-like side effects, and these can also successfully treat premature ejaculation. Clomipramine (Anafranil) in particular is exceptionally effective for the treatment of premature ejaculation. Unfortunately, antidepressants cannot simply be taken โ€˜as neededโ€™ and success depends on a medium to long-term approach to treatment. Since the long-term use of SSRIs can produce unwanted or adverse effects such as the loss of libido or even erectile dysfunction, your doctor will consider all medical factors carefully before prescribing this treatment. Antidepressants are particularly helpful in cases where depression is the primary cause of either erectile dysfunction, premature ejaculation, or both. Antidepressants are also helpful in cases where the premature ejaculation condition has caused depression. Some users see an improvement in their condition within a week, but you may usually expect improvement from around 3 to 6 weeks after starting treatment.


Certain pain medications have been found, as a side effect, to cause a delay in ejaculation. Tramadol (Ultram) is a synthetic opioid analgesic medication used to treat pain. Like SSRIs, it inhibits neuronal retake of serotonin and also nor-epinephrine and therefore, as a side effect, delays ejaculation. Although Tramadol can successfully treat premature ejaculation, constant use can lead to opioid dependency and other unwanted side effects such as sleepiness, dizziness, nausea and erectile dysfunction. Tramadol is prescribed in cases where SSRIs are not effective. Its long-term safety has not been established.

Phosphodiesterase-5 Inhibitors

PDE5 inhibitors are regarded as the current gold standard for the treatment of ED (erectile dysfunction) and allow the user to get a firm erection when in a sexually stimulating situation. Well-known PDE5 inhibitors are Viagra (Sildenafil), Cialis (Tadalafil) and Levitra (Vardenafil). Although the mechanism of action is not known, studies have shown that they are very effective for treating ED and also PE, especially when used in combination with SSRIs. PDE5 users claim that the added firmness of their erections also enhances control during sex and, as a result, helps them to last longer.



Sildenafil (Viagra) is an FDA-approved treatment for erectile dysfunction. Although it has not been FDA-approved for the treatment of PE, Viagra has been proven to help both conditions, especially when combined with SSRI treatment.


Like Viagra, Tadalafil (Cialis) is an FDA-approved drug for the treatment of ED. It is often prescribed for the specific treatment of premature ejaculation. When Cialis is combined with an SSRI, it effectively treats both ED and premature ejaculation.


Levitra (Vardenafil) is another FDA-approved drug for the treatment of erectile dysfunction which is a highly effective treatment for PE. Users experience significant increases in the time from initial penetration to ejaculation, which has greatly increased the demand for Levitra as a recreational drug.

Potential Treatment

PE affects a vast number of men โ€“ and their partners – and therefore there is a high demand for effective treatments, a permanent cure for the condition and even pills for recreational use. Ongoing exploration has highlighted several exciting drugs for further research. The most promising drugs are:


Dapoxetine (Priligy) is a member of the SSRI class of drugs and was originally developed as an antidepressant. It was, however, quickly recognized as a highly effective medicine for premature ejaculation and is now widely available as a first-line treatment for PE in Europe and elsewhere. It is now undergoing clinical trials in the US and may become the first oral pill approved by the FDA to specifically treat premature ejaculation. As this pill is taken on demand, Dapoxetine is particularly valuable for men who do not wish to take a pill every day to be prepared “just in case”.

Modafinil (Provigil)

Modafinil is a nootropic โ€“ a so-called โ€˜smart drugโ€™ – used to improve cognitive function and vigilance. It is usually prescribed to treat excessive daytime sleepiness for those who suffer from sleeping disorders, such as narcolepsy, but also shows promise as a treatment for premature ejaculation.

Silodosin (Rapaflo)

Erectile dysfunction in men

Silodosin is a drug normally prescribed to treat prostate gland enlargement and works by relaxing the muscles that control the prostate and the bladder neck to improve urination. In a 2012 study, Silodosin showed that it could delay ejaculation significantly, but in an exciting twist, also enabled a significant number of the male subjects to achieve orgasm without releasing semen (ejaculation).

Penile Injection Therapy

Penile injection therapy is a second-line therapy for Erectile Dysfunction (ED). Alprostadil is a drug which causes blood vessels to expand, and when injected into the penis, will successfully cause a firm erection in over 80% of ED sufferers, regardless of the cause of their ED or their age. This drug is very valuable for sufferers of both ED and premature ejaculation as the erection can often continue after orgasm and ejaculation. Injectable Alprostadil is known as the brand names Prostin VR, Caverject and Edex, and is also available as a suppository called โ€˜MUSEโ€™ (Medicated Urethral System for Erection). MUSE is a very small granule which you insert into the opening of the urethra using a special applicator and lubricant and is not as effective as the injection. This medication is only available on a doctorโ€™s prescription as improper use can permanently damage the penis.


There are many claims about the benefits of supplementation with almost every known vitamin. Few of these claims are backed by solid research, and in many cases, the claims consist solely of anecdotal accounts of miracle cures and unverifiable user reviews of proprietary products. However, a number of scientific studies have demonstrated a significant relationship between serum Folic Acid levels and sexual dysfunction. Folic Acid is a member of the B-vitamin group.

Where to Buy the Premature Ejaculation Pills OTC?

Premature Ejaculation Pills

PE is a real and common physiological condition which can cause significant mental and physical distress. It is best treated with the correct, scientifically formulated medication for premature ejaculation. Although desensitizing creams and sprays are available for sale over the counter (OTC) at drug stores, it is worth your while to review researched medical solutions to get the best results for your particular situation.

Remember that brick-and-mortar drugstores are not your only option to buy your PE fix. Here at, we have worked hard to earn our reputation as a respected and discreet online supplier of trusted medical solutions. Approve and download Or ask for changes.