In today’s world, many men face an erectile dysfunction (here and below ED) problem.

This happens due to constant stresses, unhealthy lifestyles, sedentary work, bad habits, and poor environmental situations.

Age changes also make themselves felt. Erectile dysfunction does not only consist of problems in a man’s sexual life, but also as a decrease in self-confidence and deterioration in relations with a partner.

The vast majority of adult men find it difficult to imagine a happy life without intimate relationships, and ED is able to turn their nightmare into a reality.

Fortunately, there are modern drugs that make erectile dysfunction treatment very effective, convenient, and simple.

PDE5 Inhibitors

ED can have different natures. If there is sexual arousal, but the erection is short-timed or weak, then the cause of it is from PDE5 (phosphodiesterase 5). These are enzymes that stop erections, so full-fledged sexual intercourse becomes impossible.

The Pfizer company in 1989 tested its own medicine named Viagra. This medicine was created to treat high blood pressure and improve blood circulation. Then, an interesting side effect was discovered – the enhancement of erection during sexual arousal. It turned out that Sildenafil, which is the main active substance of the drug, suppresses the action of PDE5. Since that time, the drug has passed many tests as a remedy for ED. As a result, after nine years, Viagra was declared to be an impotence cure and was approved by the FDA. In the same year, a drug based on sildenafil was first released to the US markets. After that, many pharmacies patented thousands of prescriptions for Viagra.

Viagra and Beyond

After the release of Viagra, the mechanism of sildenafil’s action on potency became clear. Many pharmaceutical companies are engaged in the development of substances that could suppress PDE5. For several years, such substances as Tadalafil and Vardenafil have been created. They inhibited PDE5, improved blood circulation, and relaxed the smooth muscles of the penis. All this leads to a permanent erection and makes full-fledged sexual intercourse possible. Based on tadalafil and vardenafil, such remedies as Cialis and Levitra were created.

All these drugs have the same mechanism of action, but they have significant differences. So, Viagra and Levitra work only for 4-5 hours, but Cialis allows you to successfully have sex at any time within 36 hours after intake of the pill. Male bodies can react differently to active substances, so, for some, one drug might be better, while another is better for others.

Cialis

Cialis is convenient because it does not need to be taken in advance, as it lasts up to a day and a half. It has a mild effect, so it can be taken by men after age 65 and those who have chronic illnesses (naturally, in these cases, a doctor’s consultation is needed). Cialis is available in dosages ranging from 2.5 mg to 60 mg. The standard and most commonly purchased dosage is 20 mg. It starts to act 15 minutes after use and the main part of the drug is excreted from the body after 18 hours. Cialis can be taken regardless of meals. According to studies, this drug has helped 85% of men in whom ED was observed.

Levitra

Vardenafil is effective for 4 to 5 hours. Its action is rather mild, well-tolerated, and has relatively few side effects. Levitra is good for a man who has some health problems. Naturally, in the presence of any disease you should to consult with a doctor. The cost of Levitra in the retail trade is slightly higher than the price of Cialis and Viagra. The drug is available in dosages from 10 mg to 60 mg. The common recommended dosage is 20 mg. The maximum effect is achieved one hour after use of the medicine. According to statistics, Levitra helps in 92% of cases of problems with potency.

Kamagra

Kamagra is one of the most popular generics of Viagra. Its main active substance is also sildenafil. The effect of this drug is completely identical to Viagra. Contraindications, side effects, and the mechanism and duration of action are also absolutely the same. It is available in dosages of 25, 50, and 100 mg. The optimal and most popular dosage is 100 mg. Kamagra is effective in 82% of ED cases. The main difference between this drug and Viagra is the lower price and the possibility of buying it over the counter.

Stendra

Stendra is the latest drug that was approved by the FDA and was only released on the market in 2012. Its main active component is Avanafil. This substance has the same principle of action as sildenafil, vardenafil, and tadalafil. It works very quickly, as the effect is observed 15 minutes after intake and the maximum concentration in the blood appears after 30-40 minutes. The effect of the drug is maintained for 6 hours. Dosages of the drug are the following – 50, 100, and 200 mg. For the best effect – take it 30 minutes before the intended sexual intercourse. Studies show that in more than in 80% of ED cases, Stendra helps to solve sexual problems. It is assumed that women can also use avanafil to increase excitement, but such studies have not been carried out yet. The number of side effects and contraindications in avanafil is quite small.

Other ED Medicines

There are many generics based on sildenafil, tadalafil, and vardenafil. All of them are not inferior in quality to the originals, but they have a more affordable price. If the country has a patent of the original drug, then you cannot buy generics in the state drugstore. Usually it’s easy to do through an international pharmacy, where generics can be bought OTC. The most popular generics are:

On the basis of sildenafil:

• Silagra;
• Vigora;
• Lovegra;
• Malegra;
• Edegra;
• Virecta;
• Sildigra.

On the basis of tadalafil:

• Tadalis;
• Tadapox;
• Tadagra;
• Tadasoft;
• Erectafil;
• Megalis.

Based on vardenafil:

• Vilithra;
• Viprofil;
• Snovitra;
• Filitra.

It is difficult to say which of these means is the best. All of them are non-prescription types, effective, and relatively cheap. Therefore, when choosing a drug, one must rely on individual tolerability, the necessary duration of action, and the needed dosage.

How to Choose the Best Erectile Dysfunction Drug?

Choosing a drug, a man should focus not only on its price and popularity, but also on other factors. For elderly men whose age is over 65 years, the most effective drugs will be Cialis and its generics due to the mild effect of tadalafil. Also, this drug is suitable for those who have a regular and frequent sex life, because it can be taken every 2-3 days. Cialis is not suitable for allergy sufferers. Viagra and Levitra act quickly, but the effect from them does not last so long – only 4-5 hours. These drugs are suitable for men who know beforehand when they will have sex. Levitra is convenient to all because it is the safest of all drugs. It can also be taken as “safety net” when a man does not have ED, but is not confident in own abilities and very nervous about it.

Also, it is not an uncommon case when some drug does not fit a particular man and another one is just excellent. If there is no intolerance and allergic reaction but the medicine doesn’t work, then you should change it. You need to do this after it does not bring the expected result 8 times.

If no drug has helped you, then you need to seek the cause of ED together with an andrologist.

Side Effects

PDE5 inhibitors are considered to be relatively safe. Usually they do not cause health problems. Still, no one is insured from the appearance of side effects. Fortunately, most of them are not dangerous and do not require additional treatment. They pass after withdrawal from the drug. The vast majority of men do not observe any side effects.

Here is a list of the most common side effects:

• headache;
• redness of the face and neck skin;
• disruption of the stomach and intestines work;
• impairment of vision;
• diarrhea;
• dizziness;
• hives, skin rash.

In very rare cases, a dangerous side effect can occur – priapism. This is a painful erection which doesn’t pass for over 4 hours. In this case you should immediately seek medical help.

Contraindications

The mentioned-above drugs are well-tolerated, but this applies only to people with good health. In the presence of certain diseases (both now and in the past), then the compatibility of drugs should be adjusted by a doctor.

Do not take PDE5 inhibitors if you have such problems:

• propensity to priapism;
• chronic hypotension;
• stroke or heart attack in the past six months;
• heart, kidney and liver failures;
• constant intake of nitrates.

Studies have shown that at low blood pressure, you can take tadalafil, but in this case, you should consult with a doctor.

If you do not have health problems, the ED medication should be started from a minimal dosage and gradually increased as needed.

Which PDE5 Inhibitor Is the Most Popular?

Despite the fact that all PDE5 inhibitors are characterized by efficiency and high quality, it is possible to name the TOP of the most popular ones:

1. In the first place is Viagra. The name of this drug is already synonymous with ED remedy. This is the oldest drug, it has been tested for years, and a lot of men already use it and were satisfied with the effect.
2. In second place is Cialis. It is popular due to the duration of action, which many men find very comfortable.
3. Levitra owns third place. This drug is the best choice for those who have some health problems or want to use the drug as a “safety net.”

The drug Stendra, which is based on avanafil, is not very popular yet, but this can be explained by the fact that it was released not so long ago. Most likely, over time, it will gain high popularity.

Viagra, Cialis and Levitra: Comparison Chart

Despite the fact that the cure of ED by PDE5 inhibitors is the same, these drugs have significant differences. From these differences depends on how much each drug will suit you.

The choosing of a medicine should proceed from features of your body and the expected time of work. In order to do this right, it is desirable to make a comparative analysis of sildenafil, tadalafil, and vardenafil.

How Long Does It Take To Work?

Vardenafil is considered the most fast-acting drug among the all-known inhibitors of PDE5. Its effect occurs on average after 15-30 minutes. Viagra begins to fully function in 30-60 minutes. After taking a tablet based on tadalafil, the maximum effect will come after 30-45 minutes.

This data is about the intake of pills on an empty stomach. If the pill was taken after eating fatty foods, then you must wait longer for the result.

How Long Does the Effect Last?

Cialis has the longest work time. It is about 36 hours. It is important to remember that such a long duration can lead to allergies or side effects.

Viagra lasts about 4 hours.

Levitra gives you the opportunity to have sex at any time during 4-5 hours after intake of the pill.

Percent of Effective ED Medications

Which medicine is best for the ED treatment? That all depends on what effect and duration are needed from it. The effectiveness of the drugs is approximately the same, and the differences are insignificant. It is also important to consider the health status of men and the severity of the erectile dysfunction. In mild forms of this disease (weak erection), about 83% of the men successfully cured it. If ED has a medium degree of severity, then improvements were noted by 60% of men. In severe cases, the success rate did not exceed 33%. In diabetics, the percentage of effectiveness is about 50%.

It is important to remember that all these drugs help only if a man has sexual arousal. If there is no sexual desire, then the drugs will not help and you need to look for another treatment.

Conclusion

Who should use the PDE5 inhibitors? Any man with erection problems (both physical and psychological), but who has a sexual desire. How effective they will be? It depends on the individual characteristics of the man, the severity of ED and general state of health. It does not matter which drug you choose – expensive original medicine or cheap generic. All of them are equally effective.

If you need a particular drug or you want to choose the best generic for yourself, then on our ViaBestBuy website you will find various options of them. Here you can select the best medicine for one-time or permanent use.

Our pharmacy offers favorable prices, a wide range of goods, convenient shipping. With all of this you will be able return back to an active sex life!